Postulate: “We stay young as long as our cells stay young. We live as long as our cells live.”
A telomere is “the sleeve” at the end of a DNA chromosome, which protects the chromosome from deterioration or from fusion with neighboring chromosomes creating mutations. Cell division and replication is the natural process where cells are continuously replaced with new ones. There is a limited number of times that a cell can divide, defining the chronological age and the lifespan of a person. This limited number of divisions is dependent upon the length of the telomeres. Theoretically the maximum chronological age could be around 125 years. Following each cell division the telomeres end-up shorter. Over time, due to each cell division, the telomere shortens until the cell is signaled to stop and cannot divide any longer. This is in fact the phenomenon of aging (senescence) when although the cells do not die they cease to renew and age until cellular death occurs (apoptosis). Even worse, if the telomere has reached the minimum length but the cell does not respond to the “stop” signal and continues to divide, it ends up with loose chromosomes that mutate or fuse to yield malignant cells.
A weak immune system can also be a factor of accelerated telomere shortening and subsequent aging. Telomerase enzyme is a protein enzyme produced by the body to maintain the integrity of DNA telomeres. Telomerase activation can be impeded by different stressors leading to insufficient amounts being circulated or failure to bind to the nucleus. The consequence is an accelerated telomere shortening reflected in early or accelerated aging or the onset of various degenerative diseases.
In vivo, the telomere length of replicating somatic cells is inversely correlated with age and is associated with age-related disorders, including cardiovascular disease. Associations with telomere length have been reported for essential hypertension, diabetes, insulin resistance, obesity, atherosclerosis, vascular dementia, and mortality due to heart disease as well as other degenerative diseases.
By maintaining a sound immune system and by maintaining adequate supply of telomerase enzyme, telomere length can be controlled and by this effect, degenerative diseases can be stopped, aging can be slowed down and, some effects of aging can even be reversed.
Konig Laboratorium REVITAL – TA contains an orthomolecular formulation aimed at stimulating the immune system for the release and circulation of the telomerase enzyme and at supporting continuous cell division and correct DNA replication.
What are the ingredients? A proprietary Sulphated Cycloastragenol Small Molecule and Astragaloside IV extracted and purified from the root of Astragalus spp. together with a concentrated Astragalus membranaceus extract to activate the enzyme telomerase and strengthen the immune system. IgG from Colostrum is a known factor for the maintenance of the immune system and contains factors needed for cell replication and growth.
Konig Laboratorium REVITAL – TA also contains a sequence of amino acids as co-factors in the activation of telomerase enzyme. Protein p43 found in Saccharomyces Cervisiae is involved in anchoring telomerase enzyme in the nucleus. Nucleic acids and in particular Ribonucleic (RNA) contain polynucleotides that help to stimulate correct telomere replication during cell division. All the ingredients in Konig Laboratorium REVITAL – TA act synergistically to promote DNA telomere repair, maintain telomere length and promote rejuvenation by stimulating cell division and replication.
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- The telomerase-associated protein p43 is involved in anchoring telomerase in the nucleus, Matthias Möllenbeck et al. Institute of Cell Biology, University Witten/Herdecke, Stockumer Strasse 10, D-58453 Witten, Germany, Journal of Cell Science 116, 1757-1761, 2003
- Cdc13 N-Terminal Dimerization, DNA Binding, and Telomere Length Regulation, Meghan T. Mitchell et al. MOLECULAR AND CELLULAR BIOLOGY, Nov. 2010, p. 5325–5334
- Accelerated telomere shortening in response to life stress, Elissa S. Epel et al, PNAS, December 7, 2004, vol. 101, no. 49
- Astragalus-Monograph; Alternative Medicine Review, Volume 8, Number 1, 2003
- Human telomerase contains evolutionarily conserved catalytic and structural subunits, Lea Harrington et al., Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Canada, GENES & DEVELOPMENT 11:3109–3115 © 1997
- Capsules per bottle: 60
- Capsule shell: Delayed Release vegetarian gelatin
- Dairy Free / Gluten Free / Soy Free